Selective Venous Sampling Prompting Unilateral Oophorectomy in an Adolescent With PCOS and Markedly Elevated Testosterone

BackgroundFor adolescents with suspected polycystic ovary syndrome (PCOS) and severely elevated testosterone concentrations, imaging is recommended to assess for neoplasm. Selective venous sampling (SVS) can be considered when nondiagnostic.CaseAn adolescent female treated PCOS had a peak of 344 ng/dL (11.9 nmol/L). Imaging did not localize mass. SVS implicated the right as source hyperandrogenism. Following laparoscopic oophorectomy, pathology excluded neoplasm confirmed PCOS. She subsequently rapid persistent improvement in her hyperandrogenism.Summary ConclusionStriking elevation occur tool localizing severe hyperandrogenism, yet unilaterality always diagnostic Unilateral oophorectomy could nonetheless therapeutic